诺诺诺奖
章节大纲
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What is the highest honor a scientist can be awarded?
::科学家能获得的最高荣誉是什么?The Nobel Prize is awarded each October in six categories, including physiology or medicine and chemistry.
::诺贝尔奖每年10月分六类颁发,包括生理学或医学和化学。The Nobel Prize
::诺贝尔奖The Nobel Prize is an international award given each year to honor outstanding achievements in physics, chemistry, medicine, literature and for work in peace. The award is maintained by the Nobel Foundation in Stockholm, Sweden, named after Alfred Nobel (1833-1896), a scientist, inventor, entrepreneur, author, and pacifist. At the age of 17, Alfred Nobel spoke five languages fluently. He went on to become an inventor and businessman, and at the time of his death, he had 355 patents worldwide, one of which was the patent for dynamite. More importantly, he had started 87 companies world-wide. He had an unprecedented idea for his wealth.
::诺贝尔奖是每年颁发的国际奖,以表彰在物理学、化学、医学、文学和和平工作方面取得的杰出成就,由瑞典斯德哥尔摩诺贝尔基金会(以科学家、发明家、企业家、作家和和平主义者阿尔弗雷德·诺贝尔(Alfred Nobel (1833-1896)命名)维持。 17岁时,阿尔弗雷德·诺贝尔(Alfred Nobel)说五种流利的语言。 他后来成为发明家和商人,在去世时,他在全世界拥有355项专利,其中之一是炸药专利。更重要的是,他在全世界创办了87家公司。 他对财富有着前所未有的想法。In his last will, dated November 27, 1895, Nobel left instructions for the prize. After leaving sums of monies to various friends and relatives, Nobel stated in his will, "The whole of my remaining realizable estate shall be dealt with in the following way: the capital, invested in safe securities by my executors, shall constitute a fund, the interest on which shall be annually distributed in the form of prizes to those who, during the preceding year, shall have conferred the greatest benefit to mankind. The said interest shall be divided into five equal parts, which shall be apportioned as follows: one part to the person who shall have made the most important discovery or invention within the field of physics; one part to the person who shall have made the most important chemical discovery or improvement; one part to the person who shall have made the most important discovery within the of physiology or medicine; one part to the person who shall have produced in the field of literature the most outstanding work in an ideal direction; and one part to the person who shall have done the most or the best work for fraternity between nations, for the abolition or reduction of standing armies and for the holding and promotion of peace congresses. The prizes for physics and chemistry shall be awarded by the Swedish Academy of Sciences; that for physiological or medical work by the Caroline Institute in Stockholm; that for literature by the Academy in Stockholm, and that for champions of peace by a committee of five persons to be elected by the Norwegian Storting. It is my express wish that in awarding the prizes no consideration whatever shall be given to the nationality of the candidates, but that the most worthy shall receive the prize, whether he be a Scandinavian or not."
::在1895年11月27日的最后一个遗嘱中,诺贝尔奖左派奖状。在把一笔钱留给各种朋友和亲属之后,诺贝尔遗嘱中说,“我剩下的全部可变现财产将按以下方式处理:资本,由我的执行者投资于安全证券,将构成一个基金,每年以奖项的形式向那些在上一年中为人类带来最大利益的人分配,上述利益将分为五个相等的部分,分配如下:一部分给那些在物理领域作出最重要发现或发明的人;一部分给那些将作出最重要发现或发明的人;一部分给那些将作出最重要化学发现或改进的人;一部分给那些在物理或医学领域作出最重要发现或改进的人;一部分给那些在斯德哥尔摩文学领域作出最杰出工作的人;一部分给那些为国家间兄弟事业作出最大或最佳工作的人;一部分给人,为废除或减少在任何在物理领域作出最显著的发现或发明;一部分给人;一部分给人的奖品奖项,由我所选的物理学和物理学奖项,由斯德哥尔摩科学院作出,由他为该奖项颁发的奖品级奖品奖。The first five Nobel Prizes were awarded in 1901. In 1969, another prize was added: "The Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel."
::1901年颁发了头五个诺贝尔奖。1969年又增加了另一个奖项:“斯韦里盖斯·瑞克斯班克纪念阿尔弗雷德·诺贝尔经济学科学奖”。Many of the contributions of Nobel laureates are discussed throughout these concepts. The contributions from the physiology or medicine are directly related to the life sciences, as are selected contributions from the chemistry prize.
::在这些概念中,讨论了诺贝尔奖获得者的许多贡献,生理学或医学的贡献与生命科学直接相关,化学奖的一些贡献也直接相关。Physiology or Medicine
::生理或医学Year Laureates Contribution Concept 2014 John O'Keefe, May-Britt Moser, Edvard I. Moser for their discoveries of that constitute a positioning system in the brain 2013 James E. Rothman, Randy W. Schekman, Thomas C. Südhof for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells : Exocytosis and Endocytosis (Advanced) 2012 Sir John B. Gurdon, Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent 2011 Bruce A. Beutler, Jules A. Hoffmann, Ralph M. Steinman for their discoveries concerning the activation of innate (BAB, JAH) and for his discovery of the dendritic cell and its role in adaptive immunity (RMS) 2010 Robert G. Edwards for the of in vitro 2009 Elizabeth H. Blackburn, Carol W. Greider, Jack W. Szostak for the discovery of how are protected by telomeres and the telomerase 2008 Harald zur Hausen, Françoise Barré-Sinoussi, Luc Montagnier for his discovery of human papilloma causing cervical cancer (HzH) and for their discovery of human immunodeficiency virus (FB-S, LM) 2007 Mario R. Capecchi, Sir Martin J. Evans, Oliver Smithies for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic cells Human Genetics : The (Advanced) 2006 Andrew Z. Fire, Craig C. Mello for their discovery of interference - gene silencing by double-stranded RNA RNA: Types (Advanced) 2005 Barry J. Marshall, J. Robin Warren for their discovery of the Helicobacter pylori and its role in gastritis and peptic ulcer disease 2004 Richard Axel, Linda B. Buck for their discoveries of odorant receptors and the organization of the olfactory system 2003 Paul C. Lauterbur, Sir Peter Mansfield for their discoveries concerning magnetic resonance imaging 2002 Sydney Brenner, H. Robert Horvitz, John E. Sulston for their discoveries concerning genetic regulation of organ development and programmed cell death 2001 Leland H. Hartwell, Tim Hunt, Sir Paul M. Nurse for their discoveries of key regulators of the 2000 Arvid Carlsson, Paul Greengard, Eric R. Kandel for their discoveries concerning signal transduction in the 1999 Günter Blobel for the discovery that have intrinsic signals that govern their transport and localization in the cell 1998 Robert F. Furchgott, Louis J. Ignarro, Ferid Murad for their discoveries concerning nitric oxide as a signalling molecule in the 1997 Stanley B. Prusiner for his discovery of Prions - a new biological principle of infection 1996 Peter C. Doherty, Rolf M. Zinkernagel for their discoveries concerning the specificity of the cell mediated immune defense 1995 Edward B. Lewis, Christiane Nüsslein-Volhard, Eric F. Wieschaus for their discoveries concerning the genetic control of early embryonic development Regulation of :Eukaryotic (Advanced) 1994 Alfred G. Gilman, Martin Rodbell for their discovery of G-proteins and the role of these proteins in signal transduction in cells 1993 Richard J. Roberts, Phillip A. Sharp for their discoveries of split genes Technology: Gene Cloning (Advanced) 1992 Edmond H. Fischer, Edwin G. Krebs for their discoveries concerning reversible protein phosphorylation as a biological regulatory mechanism 1991 Erwin Neher, Bert Sakmann for their discoveries concerning the function of single ion channels in cells 1990 Joseph E. Murray, E. Donnall Thomas for their discoveries concerning organ and cell transplantation in the treatment of human disease 1989 J. Michael Bishop, Harold E. Varmus for their discovery of the cellular origin of retroviral oncogenes Cell Cycle: (Advanced) 1988 Sir James W. Black, Gertrude B. Elion, George H. Hitchings for their discoveries of important principles for drug treatment 1987 Susumu Tonegawa for his discovery of the genetic principle for generation of antibody diversity 1986 Stanley Cohen, Rita Levi-Montalcini for their discoveries of growth factors 1985 Michael S. Brown, Joseph L. Goldstein for their discoveries concerning the regulation of cholesterol metabolism 1984 Niels K. Jerne, Georges J.F. Köhler, César Milstein for theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies 1983 Barbara McClintock for her discovery of mobile genetic elements 1982 Sune K. Bergström, Bengt I. Samuelsson, John R. Vane for their discoveries concerning prostaglandins and related biologically active substances 1981 Roger W. Sperry, David H. Hubel, Torsten N. Wiesel for his discoveries concerning the functional specialization of the cerebral hemispheres (RWS), and for their discoveries concerning information processing in the visual system (DHH, TNW) 1980 Baruj Benacerraf, Jean Dausset, George D. Snell for their discoveries concerning genetically determined structures on the cell surface that regulate immunological reactions 1979 Allan M. Cormack, Godfrey N. Hounsfield for the development of computer assisted tomography 1978 Werner Arber, Daniel Nathans, Hamilton O. Smith for the discovery of restriction enzymes and their application to problems of DNA Technology: Gene Cloning (Advanced) 1977 Roger Guillemin, Andrew V. Schally, Rosalyn Yalow for their discoveries concerning the peptide production of the brain (RG, AVS) and for the development of radioimmunoassays of peptide hormones (RY) 1976 Baruch S. Blumberg, D. Carleton Gajdusek for their discoveries concerning new mechanisms for the origin and dissemination of 1975 David Baltimore, Renato Dulbecco, Howard Martin Temin for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell Viruses: (Advanced) 1974 Albert Claude, Christian de Duve, George E. Palade for their discoveries concerning the structural and functional organization of the cell 1973 Karl von Frisch, Konrad Lorenz, Nikolaas Tinbergen for their discoveries concerning organization and elicitation of individual and patterns 1972 Gerald M. Edelman, Rodney R. Porter for their discoveries concerning the chemical structure of antibodies 1971 Earl W. Sutherland, Jr. for his discoveries concerning the mechanisms of the action of hormones 1970 Sir Bernard Katz, Ulf von Euler, Julius Axelrod for their discoveries concerning the humoral transmittors in the nerve terminals and the mechanism for their storage, release and inactivation 1969 Max Delbrück, Alfred D. Hershey, Salvador E. Luria for their discoveries concerning the replication mechanism and the genetic structure of viruses 1968 Robert W. Holley, Har Gobind Khorana, Marshall W. Nirenberg for their interpretation of the and its function in 1967 Ragnar Granit, Haldan Keffer Hartline, George Wald for their discoveries concerning the primary physiological and chemical visual processes in the eye 1966 Peyton Rous, Charles Brenton Huggins for his discovery of tumour-inducing viruses (PR) and for his discoveries concerning hormonal treatment of prostatic cancer (CBH) 1965 François Jacob, André Lwoff, Jacques Monod for their discoveries concerning genetic control of enzyme and virus synthesis Regulation of Gene Expression: Introduction (Advanced) 1964 Konrad Bloch, Feodor Lynen for their discoveries concerning the mechanism and regulation of the cholesterol and fatty acid metabolism 1963 Sir John Carew Eccles, Alan Lloyd Hodgkin, Andrew Fielding Huxley for their discoveries concerning the ionic mechanisms involved in excitation and inhibition in the peripheral and central portions of the nerve 1962 Francis Harry Compton Crick, James Dewey Watson, Maurice Hugh Frederick Wilkins for their discoveries concerning the molecular structure of and its significance for information transfer in living material DNA: The Double Helix (Advanced) 1961 Georg von Békésy for his discoveries of the physical mechanism of stimulation within the cochlea 1960 Sir Frank Macfarlane Burnet, Peter Brian Medawar for discovery of acquired immunological tolerance 1959 Severo Ochoa, Arthur Kornberg for their discovery of the mechanisms in the biological synthesis of ribonucleic acid and deoxyribonucleic acid 1958 George Wells Beadle, Edward Lawrie Tatum, Joshua Lederberg for their discovery that genes act by regulating definite chemical events (GWB, ELT) and for his discoveries concerning genetic recombination and the organization of the genetic material of bacteria 1957 Daniel Bovet for his discoveries relating to synthetic compounds that inhibit the action of certain body substances, and especially their action on the vascular system and the 1956 André Frédéric Cournand, Werner Forssmann, Dickinson W. Richards for their discoveries concerning heart catheterization and pathological changes in the 1955 Axel Hugo Theodor Theorell for his discoveries concerning the nature and mode of action of oxidation enzymes 1954 John Franklin Enders, Thomas Huckle Weller, Frederick Chapman Robbins for their discovery of the ability of poliomyelitis viruses to grow in cultures of various types of tissue 1953 Hans Adolf Krebs, Fritz Albert Lipmann for his discovery of the citric acid cycle (HAK) and for his discovery of co-enzyme A and its importance for intermediary metabolism (FAL) 1952 Selman Abraham Waksman for his discovery of streptomycin, the first antibiotic effective against tuberculosis 1951 Max Theiler for his discoveries concerning yellow fever and how to combat it 1950 Edward Calvin Kendall, Tadeus Reichstein, Philip Showalter Hench for their discoveries relating to the hormones of the adrenal cortex, their structure and biological effects Year Laureates Contribution Concept 1945 Sir Alexander Fleming, Ernst B. Chain, Sir Howard Florey for the discovery of penicillin and its curative effect in various infectious diseases : Uses (Advanced) 1935 Hans Spemann for his discovery of the organizer effect in embryonic development 1933 Thomas H. Morgan for his discoveries concerning the role played by the chromosome in heredity Human Genetics: Chromosomes (Advanced) 1905 Robert Koch for his investigations and discoveries in relation to tuberculosis : Diseases (Advanced) 1902 Ronald Ross for his work on malaria , by which he has shown how it enters the organism and thereby has laid the foundation for successful research on this disease and methods of combating it Animal-like : Diseases (Advanced) Chemistry
::化学化学The following are the Nobel Prizes in Chemistry that have significance to the life sciences.
::以下是对生命科学具有重要意义的诺贝尔化学奖。Chemistry Year Laureates Contribution Concept 2013 Martin Karplus, Michael Levitt, Arieh Warshel for the development of multiscale models for complex chemical systems 2012 Robert J. Lefkowitz, Brian K. Kobilka for studies of G-protein-coupled receptors 2009 Venkatraman Ramakrishnan, Thomas A. Steitz, Ada E. Yonath for studies of the structure and function of the 2006 Roger D. Kornberg for his studies of the molecular basis of eukaryotic The Chromosome - Advanced 2004 Aaron Ciechanover, Avram Hershko, Irwin Rose for the discovery of ubiquitin-mediated protein degradation 2003 Peter Agre, Roderick MacKinnon for discoveries concerning channels in cell membranes 1997 Paul D. Boyer, John E. Walker, Jens C. Skou for their elucidation of the enzymatic mechanism underlying the synthesis of adenosine triphosphate (PDB, JEW) and for the first discovery of an ion-transporting enzyme, Na + , K + -ATPase (JCS) 1993 Kary B. Mullis, Michael Smith for his invention of the polymerase chain reaction (PCR) method (KBM) and for his fundamental contributions to the establishment of oligonucleotide-based, site-directed mutagenesis and its development for protein studies (MS) The Polymerase Chain Reaction - Advanced 1989 Sidney Altman, Thomas R. Cech for their discovery of catalytic properties of RNA 1988 Johann Deisenhofer, Robert Huber, Hartmut Michel for the determination of the three-dimensional structure of a photosynthetic reaction centre 1982 Aaron Klug for his development of crystallographic electron microscopy and his structural elucidation of biologically important nucleic acid-protein complexes 1980 Paul Berg, Walter Gilbert, Frederick Sanger for his fundamental studies of the biochemistry of nucleic acids, with particular regard to recombinant-DNA (PB) and for their contributions concerning the determination of base sequences in nucleic acids (WG, FS) - Advanced 1978 Peter D. Mitchell for his contribution to the understanding of biological energy transfer through the formulation of the chemiosmotic theory 1972 Christian B. Anfinsen, Stanford Moore, William H. Stein for his work on ribonuclease, especially concerning the connection between the amino acid sequence and the biologically active conformation (CBA) and for their contribution to the understanding of the connection between chemical structure and catalytic activity of the active centre of the ribonuclease molecule (SM, WHS) 1970 Luis F. Leloir for his discovery of sugar nucleotides and their role in the biosynthesis of 1962 Max Ferdinand Perutz, John Cowdery Kendrew for their studies of the structures of globular proteins 1961 Melvin Calvin for his research on the carbon dioxide assimilation in plants 1958 Frederick Sanger for his work on the structure of proteins, especially that of insulin 1954 *Linus Carl Pauling for his research into the nature of the chemical bond and its application to the elucidation of the structure of complex substances
::研究化学联结的性质及其对阐明复杂物质结构的应用*Linus Pauling was also awarded the Nobel Peace Prize in 1962
::*莱纳斯·保林也获1962年诺贝尔和平奖